Prevention of irinotecan associated diarrhea by intestinal alkalization. A pilot study in gastrointestinal cancer patients
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چکیده
منابع مشابه
Intestinal alkalization as a possible preventive mechanism in irinotecan (CPT-11)-induced diarrhea.
The therapeutic efficacy of irinotecan (CPT-11), a DNA topoisomerase inhibitor, is often limited by the induction of severe late-onset diarrhea. This prodrug and its active metabolite, 7-ethyl-10-hydroxy-camptothecin (SN-38), have a labile alpha-hydroxy-lactone ring that undergoes pH-dependent reversible hydrolysis. At physiological pH and higher, equilibrium favors the less toxic carboxylate f...
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ژورنال
عنوان ژورنال: Clinical and Translational Oncology
سال: 2006
ISSN: 1699-048X,1699-3055
DOI: 10.1007/s12094-006-0188-4